| SNBRN | Lovin' Me | Original Mix | 125 | House | Original Mix | 2018 |
| SNBRN ft. Kaleena Zanders | California | Chris Lake & Matroda Remix | 125 | Dance | Ultra | 2015 |
| SR | Koinz | Riddler Extended - Explicit | 125 | House | I AM SR LLC | 2017 |
| STASH | Strip Me Bare | Cutmore Remix | 125 | Dance | SAS Entertainment | 2015 |
| Sabrina Carpenter | Sue Me | A Cappella Version | 125 | Top 40 | A Cappella Version | 2019 |
| Safety Groove | Sweet Dreams | Bootleg Mix | 125 | — | Zyx Records | 1996 |
| Saint Motel | Van Horn | — | 125 | AlternRock | — | 2019 |
| Salah ft. Isaac | Shine Through | Davidson Ospina Remix | 125 | — | Ospina Digital | 2010 |
| Salvatore Vitrano | Bad Boys | Original Mix - Explicit | 125 | — | Henry Street | 2013 |
| Salvatore Vitrano | One More Disco | Main Mix | 125 | Dance | Henry Street | 2013 |
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| Sam & The Womp | Bom Bom | — | 125 | Dance | Warner Bros | 2012 |
| Sam Aparrow | Black And Gold | — | 125 | Pop | — | 2008 |
| Sam Feldt & Hook N Sling | Open Your Eyes | Club Intro Edit | 125 | — | Spinnin | 2017 |
| Sam Feldt & Hook N Sling | Open Your Eyes | Club Mix | 125 | Electronica | Spinnin | 2017 |
| Sam Feldt ft. Ella Henderson | Hold Me Close | Radio Edit | 125 | Dance | Radio Edit | 2020 |
| Sam Feldt ft. Ella Henderson | Hold Me Close | Extended Mix | 125 | House | Extended Mix | 2020 |
| Samantha Mumba | Baby Come Over (This Is Our Night) | K-Klass Club Edit* | 125 | — | A&M/Polydor Records | 2007 |
| Samantha Mumba | Baby Come Over (this Is Our Night) | K-klass Club Mix | 125 | — | Wildcard/a&m/polydor Records | 2001 |
| Samim | Heater | — | 125 | Rock | Ministry Of Sound | 2010 |
| Sammy Kershaw | Honky Tonk America | — | 125 | — | Mercury Records | 1998 |
|
| Samuele Sartini ft. Amanda Wilson | Love You Seek | Beat Thrillerz Remix | 125 | — | Nervous | 2011 |
| Sander Kleinenberg | This Is Our Night | Original | 125 | — | Ultra | 2009 |
| Sander Kleinenberg | This Is Our Night | Sultan vs Ned Shepard Remix | 125 | — | Ultra | 2009 |
| Sander Van Doorn | By Any Demand | Peter Gelderblom Remix | 125 | — | Nebula | 2007 |
| Sandy Y Junior | Convence Al Corazon | Spanish Fly Remix | 125 | — | Universal Music Latino | 2002 |