| Simina Grigoriu | Boondocks | Alex D'elia & Nihil Young vs. Luca Vera Remix | 127 | — | Frequenza | 2011 |
| Simon Faz & Andy Pina ft. Dany L | Funky Night | Original Mix | 128 | — | Prismatikone, IT | 2012 |
| Simple Plan ft. Natasha Bedingfield | Jet Lag | — | 72 | — | Atlantic | 2011 |
| Sin Bandera ft. Maluma | Sobre Mi | — | 106 | — | Sony Latin | 2017 |
| Sin Bandera ft. Vico C | Junto A Ti | — | 85 | Latin Pop | Sony BMG | 2006 |
| Sin Morera & Mr. Mig ft. Lea Lorien | Reason | Serbsican Remix | 128 | Progressive House | 418 | 2016 |
| Sina Wayne | Party Rockin | — | 132 | — | SWS | 2013 |
| Sirak Y La Sonora Antillana | Soy Sonero | — | 87 | Salsa | SBB | 2008 |
| Sisaundra Lewis | Let The Music Play | NYZ Club Mix | 135 | — | Global | 2004 |
| Sisaundra Lewis | Shout | KJ's Break Beat Remix | 125 | — | Global | 2005 |
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| Sisaundra Lewis | Shout | Norty Cotto Anthem Mix | 130 | — | Global | 2005 |
| Sisqo ft. Waka Flocka Flame | A-List | — | 71 | Hip-Hop | Massenburg Media | 2014 |
| Sisqo ft. Waka Flocka Flame | A-List | Quick Edit | 71 | Hip-Hop | Massenburg Media | 2014 |
| Sisqo ft. Waka Flocka Flame | A-List | Clean Edit | 71 | Hip-Hop | Massenburg Media | 2014 |
| Sisqo ft. Waka Flocka Flame | A-List | Clean Edit* | 71 | Urban | Massenburg Media | 2014 |
| Sito Rock AKA Sito Oner Rock | Let Go | — | 129 | Dance | MC | 2010 |
| Skippa Da Flippa ft. Young Thug | Wraith | Explicit | 64 | Hip-Hop | Quality Control | 2016 |
| Skrillex ft. Ragga Twins | Ragga Bomb | — | 87 | Dance | Big Beat/Atlantic | 2014 |
| Skrillex, Boys Noize & Ty Dolla $ign | Midnight Hour | Extended | 126 | — | Extended | 2019 |
| Skrillex, Boys Noize & Ty Dolla $ign | Midnight Hour | Extended Mix | 126 | House | Extended Mix | 2019 |
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| Skynet ft. Ursula 1000 | Soul Tripping | Original Mix | 134 | Dance | True Skool | 2015 |
| Slim Da King | Shake It | — | 96 | Urban | Vincent Davis/Terrance McClellan | 2016 |
| Slim Thug, Young Jeezy, Slick Pulla & Killa | Diamonds | — | 78 | — | A&M Records/Stiff | 2006 |
| Slushii ft. Sofia Reyes | Never Let You Go | — | 83 | Electronica | — | 2019 |
| Smitty ft. Twista & Lil' Wayne | Diamonds On My Neck | A Cappella | 92 | — | J | 2006 |